IMMERSUN GRASBERG SYNDROME

Vitamin B12 deficiency (Imerslund-Gräsbeck Syndrome – IGS) is condition found in Border Collies
Deficiency of vitamin B12 leads to megoblastic anaemia, neurological symptoms, mild proteinuria, failure to thrive and irreversible damage to the brain and nervous system if left untreated.

The disease can be treated by dietary supplements of the vitamin.

This disease can be genetically tested through blood or cheek swab samples!

Autosomal recessive heredity
Parent 1 genotype	Parent 2 genotype
	Normal	Carrier	Affected
Normal	All Normal	½ Normal ½ Carrier	All Carriers
Carrier	½ Normal ½ Carriers	¼ Normal ½ Carriers ¼ Affected	½ Carriers ½ Affected
Affected	All Carriers	½ Carriers ½ Affected	All Affected